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Title: Synthesis and evaluation of Artemisinin-based hybrid and dimer derivatives as antimelanoma agents
Filippi, Silvia
Bizzarri, Bruno M.
Zippilli, Claudio
Meschini, Roberta
Pogni, Rebecca 
Baratto, Maria Camilla 
Villanova, Luciano
Saladino, Raffaele
Issue Date: 2020
Project: None 
Journal: ACS OMEGA
A library of hybrid and dimer compounds based on the natural scaffold of artemisinin was synthesized. These derivatives were obtained by coupling of artemisinin derivatives, artesunate, and dihydroartemisinin with a panel of phytochemical compounds. The novel artemisinin-based hybrids and dimers were evaluated for their anticancer activity on a cervical cancer cell line (HeLa) and on three complementary metastatic melanoma cancer cell lines (SK-MEL3, SK-MEL24, and RPMI-7951). Two hybrid compounds obtained by coupling of artesunate with eugenol and tyrosol, and one of the dimer compounds containing curcumin, emerged as the most active and cancer-selective derivatives.
ISSN: 2470-1343
DOI: 10.1021/acsomega.9b02600
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