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|Title:||Synthesis and evaluation of Artemisinin-based hybrid and dimer derivatives as antimelanoma agents||Authors:||BOTTA, LORENZO
Bizzarri, Bruno M.
Baratto, Maria Camilla
|Issue Date:||2020||Project:||None||Journal:||ACS OMEGA||Abstract:||
A library of hybrid and dimer compounds based on the natural scaffold of artemisinin was synthesized. These derivatives were obtained by coupling of artemisinin derivatives, artesunate, and dihydroartemisinin with a panel of phytochemical compounds. The novel artemisinin-based hybrids and dimers were evaluated for their anticancer activity on a cervical cancer cell line (HeLa) and on three complementary metastatic melanoma cancer cell lines (SK-MEL3, SK-MEL24, and RPMI-7951). Two hybrid compounds obtained by coupling of artesunate with eugenol and tyrosol, and one of the dimer compounds containing curcumin, emerged as the most active and cancer-selective derivatives.
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