Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6879
DC FieldValueLanguage
dc.contributor.authorSantucci, Annalisaen_us
dc.contributor.authorBernardini, Giuliaen_us
dc.contributor.authorBraconi, Danielaen_us
dc.contributor.authorPetricci, Elenaen_us
dc.contributor.authorManetti, Fabrizioen_us
dc.date.accessioned2021-03-30T16:06:38Z-
dc.date.available2021-03-30T16:06:38Z-
dc.date.issued2017-
dc.identifier.issn0022-2623en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/6879-
dc.description103998en_US
dc.description.abstractThis review mainly focuses on the physiological function of 4-hydroxyphenylpyruvate dioxygenase (HPPD), as well as on the development and application of HPPD inhibitors of several structural classes. Among them, one illustrative example is represented by compounds belonging to the class of triketone compounds. They were discovered by serendipitous observations on weed growth and were developed as bleaching herbicides. Informed reasoning on nitisinone (NTBC, 14), a triketone that failed to reach the final steps of the herbicidal design and development process, allowed it to become a curative agent for type I tyrosinemia (T1T) and to enter clinical trials for alkaptonuria. These results boosted the research of new compounds able to interfere with HPPD activity to be used for the treatment of the tyrosine metabolism-related diseases.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofJOURNAL OF MEDICINAL CHEMISTRYen_US
dc.title4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseasesen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/acs.jmedchem.6b01395en_US
dc.identifier.pmid28128559en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0001-6976-9086-
crisitem.author.orcid0000-0003-0016-0728-
crisitem.author.orcid0000-0002-9657-4169-
crisitem.author.orcid0000-0002-9685-6342-
crisitem.author.orcid0000-0002-9598-2339-
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