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Title: Modulation of cutaneous scavenger receptor B1 levels by exogenous stressors impairs "in vitro" wound closure
Authors: Muresan, Ximena Maria
Sticozzi, Claudia
Belmonte, Giuseppe
Savelli, Vinno
Evelson, Pablo
Valacchi, Giuseppe
Keywords: Cigarette smoke; Oxidative stress; Ozone; Particulate matter; Pollution; RHE; Skin; Wound healing
Issue Date: 2017
Project: None 
Scavenger receptor B1 (SR-B1) is a trans-membrane protein, involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids levels. Among the tissues where it is localized, SR-B1 has been shown to be significantly expressed in human epidermis. Our group has demonstrated that SR-B1 levels are down-regulated in human cultured keratinocytes by environmental stressors, such as cigarette smoke, via cellular redox imbalance. Our present study aimed to investigate whether such down-regulation was confirmed in a 3D skin model and under other environmental challengers such as particulate matter and ozone. We also investigated the association between oxidation-induced SR-B1 modulation and impaired wound closure. The data obtained showed that not only cigarette, but also the other environmental stressors reduced SR-B1 expression in epidermal cutaneous tissues and that this effect might be involved in impaired wound healing.
ISSN: 0047-6374
DOI: 10.1016/j.mad.2017.11.006
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