Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6828
Title: Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors
Authors: Panecka-Hofman, Joanna
Pöhner, Ina
Spyrakis, Francesca
Zeppelin, Talia
Di Pisa, Flavio
Dello Iacono, Lucia
Bonucci, Alessio
Quotadamo, Antonio
Venturelli, Alberto
Mangani, Stefano 
Costi, Maria Paola
Wade, Rebecca C.
Keywords: Anti-parasitic drug; Enzyme inhibitor; Folate pathway; Selective inhibition; Structure-based drug design; Trypanosomatids; Binding Sites; Crystallography; Folic Acid Antagonists; Humans; Multienzyme Complexes; Oxidoreductases; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trypanocidal Agents; Trypanosoma cruzi; Drug Discovery; Biophysics; Biochemistry; Molecular Biology
Issue Date: 2017
Project: None 
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Description: 
129983
URI: http://hdl.handle.net/20.500.12779/6828
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2017.09.012
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