Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6790
Title: Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands
Authors: Ghosh, Arun K.
Sean Fyvie, W.
Brindisi, Margherita 
Steffey, Melinda
Agniswamy, Johnson
Wang, Yuan-Fang
Aoki, Manabu
Amano, Masayuki
Weber, Irene T.
Mitsuya, Hiroaki
Keywords: Drug resistance; HIV protease; Macrocyclic inhibitors; P1'-P2' ligands; Structure-based design; Binding Sites; Crystallography, X-Ray; HIV Protease; HIV Protease Inhibitors; HIV-1; Inhibitory Concentration 50; Ligands; Macrocyclic Compounds; Molecular Dynamics Simulation; Mutation; Protein Structure, Tertiary; Pyrrolidinones; Structure-Activity Relationship; Drug Design; Biochemistry; Molecular Medicine; Molecular Biology; 3003; Drug Discovery3003 Pharmaceutical Science; Clinical Biochemistry; Organic Chemistry
Issue Date: 2017
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Description: 
126203
URI: http://hdl.handle.net/20.500.12779/6790
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2017.09.003
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