Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6787
Title: Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands
Authors: Ghosh, Arun K.
Brindisi, Margherita 
Yen, Yu-Chen
Cã¡rdenas, Emilio L.
Ella-Menye, Jean-Rene
Kumaragurubaran, Nagaswamy
Huang, Xiangping
Tang, Jordan
Mesecar, Andrew D.
Keywords: Alzheimer's disease; BACE-1; Memapsin 2; Protease inhibitors; β-Secretase; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Phthalic Acids; Piperazines; Structure-Activity Relationship; Biochemistry; Molecular Medicine; Molecular Biology; 3003; Drug Discovery3003 Pharmaceutical Science; Clinical Biochemistry; Organic Chemistry
Issue Date: 2017
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Description: 
126205
URI: http://hdl.handle.net/20.500.12779/6787
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2017.04.011
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