Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6786
Title: Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex
Authors: Ghosh, Arun K.
Brindisi, Margherita 
Nyalapatla, Prasanth R.
Takayama, Jun
Ella-Menye, Jean-Rene
Yashchuk, Sofiya
Agniswamy, Johnson
Wang, Yuan-Fang
Aoki, Manabu
Amano, Masayuki
Weber, Irene T.
Mitsuya, Hiroaki
Keywords: Drug-resistance; HIV-1 protease; Isophthalamide; Synthesis; X-ray structure; Amides; Crystallography, X-Ray; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Molecular Docking Simulation; Phthalic Acids; Drug Design; Biochemistry; Molecular Medicine; Molecular Biology; 3003; Drug Discovery3003 Pharmaceutical Science; Clinical Biochemistry; Organic Chemistry
Issue Date: 2017
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY
Description: 
126201
URI: http://hdl.handle.net/20.500.12779/6786
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2017.04.005
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