Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6735
DC FieldValueLanguage
dc.contributor.authorKhanfar, Mohammad Aen_us
dc.contributor.authorAffini, Annaen_us
dc.contributor.authorLutsenko, Kirilen_us
dc.contributor.authorNikolic, Katarinaen_us
dc.contributor.authorButini, Stefaniaen_us
dc.contributor.authorStark, Holgeren_us
dc.date.accessioned2021-03-30T16:05:29Z-
dc.date.available2021-03-30T16:05:29Z-
dc.date.issued2016-
dc.identifier.issn1662-4548en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/6735-
dc.description88800en_US
dc.description.abstractWith the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been tested for a variety of different indications, the combination of pharmacological properties in one molecule for improved pharmacological effects and reduced unwanted side-effects is rationally based on the increasing knowledge on the complex neurotransmitter regulations. The polypharmacological approaches on histamine H3 receptor antagonists on different G-protein coupled receptors, transporters, enzymes as well as on NO-signaling mechanism are described, supported with some lead structures.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofFRONTIERS IN NEUROSCIENCEen_US
dc.subjectGPCR; NO; enzymes; histamine; multiple targeting; transporteren_US
dc.titleMultiple Targeting Approaches on Histamine H3 Receptor Antagonistsen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fnins.2016.00201en_US
dc.identifier.pmid27303254en_US
dc.identifier.scopuss2.0-84973575248en_US
dc.identifier.isi000376632300001en_US
dc.relation.volume10en_US
dc.description.firstpage201en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-8471-0880-
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