Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6735
Title: Multiple Targeting Approaches on Histamine H3 Receptor Antagonists
Authors: Khanfar, Mohammad A
Affini, Anna
Lutsenko, Kiril
Nikolic, Katarina
Butini, Stefania 
Stark, Holger
Keywords: GPCR; NO; enzymes; histamine; multiple targeting; transporter
Issue Date: 2016
Project: None 
Journal: FRONTIERS IN NEUROSCIENCE
Abstract: 
With the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been tested for a variety of different indications, the combination of pharmacological properties in one molecule for improved pharmacological effects and reduced unwanted side-effects is rationally based on the increasing knowledge on the complex neurotransmitter regulations. The polypharmacological approaches on histamine H3 receptor antagonists on different G-protein coupled receptors, transporters, enzymes as well as on NO-signaling mechanism are described, supported with some lead structures.
Description: 
88800
URI: http://hdl.handle.net/20.500.12779/6735
ISSN: 1662-4548
DOI: 10.3389/fnins.2016.00201
Appears in Collections:Publications

Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.