Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6730
Title: Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis
Authors: Maquiaveli, Claudia C
Lucon Júnior, João F
BROGI, SIMONE
Campiani, Giuseppe 
Gemma, Sandra 
Vieira, Paulo C
Silva, Edson R.
Issue Date: 2016
Project: None 
Journal: JOURNAL OF NATURAL PRODUCTS
Abstract: 
Verbascoside (1) is a phenylethanoid glycoside that has antileishmanial activity against Leishmania infantum and Leishmania donovani. In this study, we verified the activity of 1 on Leishmania amazonensis and arginase inhibition. Compound 1 showed an EC50 of 19 μM against L. amazonensis promastigotes and is a competitive arginase inhibitor (Ki = 0.7 μM). Docking studies were performed to assess the interaction of 1 with arginase at the molecular level. Arginase is an enzyme of the polyamine biosynthesis pathway that is important to parasite infectivity, and the results of our study suggest that 1 could be useful to develop new approaches for treating leishmaniasis.
Description: 
205261
URI: http://hdl.handle.net/20.500.12779/6730
ISSN: 0163-3864
DOI: 10.1021/acs.jnatprod.5b00875
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