Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6570
Title: Improving photoprotection: 4-Methylbenzylidene Camphor Microsphres
Authors: Centini, Marisanna 
Miraglia, Giovanna
Quaranta, Valeria
Buonocore, Anna
Anselmi, Cecilia
Keywords: Microspheres; 4-Methylbenzylidene camphor; Photoprotection,; Photostability
Issue Date: 2015
Project: None 
Journal: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
Abstract: 
We propose a new approach for photoprotection. 4-Methylbenzylidene camphor (4-MBC), one of the most widely used UV filters, was encapsulated in microspheres, with a view to overcoming problems (percutaneous absorption, photodegradation, lack of lasting effect) arising with organic sunscreens, and to achieve safe photoprotection. We focused on this filter in the light of the Cosmetics Europe opinion concerning its possible effects on the thyroid gland. Microspheres were prepared by emulsification-solvent evaporation, using different amounts of 4-MBC and characterized for morphology, encapsulation efficiency and particle size. The particles were then mixed in O/W emulsions. The in vitro sun protection factors (SPF), in vitro release and photostability were investigated and compared with emulsions containing the free sunscreen. The new microspheres offer good morphology and loading (up to 40%), and the same photoprotection as the free filter while at the same time protecting it from photodegradation. The systems also give a slower release from the emulsions.
Description: 
134603
URI: http://hdl.handle.net/20.500.12779/6570
ISSN: 1083-7450
DOI: 10.3109/10837450.2014.920359
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