Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6534
DC FieldValueLanguage
dc.contributor.authorJumde, Vren_us
dc.contributor.authorPetricci, Een_us
dc.contributor.authorPetrucci, Cen_us
dc.contributor.authorSantillo, Nen_us
dc.contributor.authorTaddei, Men_us
dc.contributor.authorVaccaro, L2.en_us
dc.date.accessioned2021-03-30T16:04:01Z-
dc.date.available2021-03-30T16:04:01Z-
dc.date.issued2015-
dc.identifier.issn1523-7060en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/6534-
dc.description76150en_US
dc.description.abstractPhenols can be efficiently reduced by sodium formate and Pd/C as the catalyst in water and in the presence of amines to give the corresponding cyclohexylamines. This reaction works at rt for 12 h or at 60 °C under microwave dielectric heating for 20 min. With the exception of aniline, primary, secondary amines, amino alcohols, and even amino acids can be used as nucleophiles. The reductive process is based on a sustainable hydrogen source and a catalyst that can be efficiently recovered and reused. The protocol was developed into a continuous-flow production of cyclohexylamines in gram scale achieving very efficient preliminary results (TON 32.7 and TOF 5.45 h-1).en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofORGANIC LETTERSen_US
dc.titleDomino Hydrogenation-Reductive Amination of Phenols, a Simple Process To Access Substituted Cyclohexylaminesen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/acs.orglett.5b01842en_US
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84939832267&partnerID=40&md5=f8321160a6d7d802adc4deccfba55cf5en_US
dc.relation.volume17en_US
dc.relation.issue16en_US
dc.description.firstpage3990en_US
dc.description.lastpage3993en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
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