Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6534
Title: Domino Hydrogenation-Reductive Amination of Phenols, a Simple Process To Access Substituted Cyclohexylamines
Authors: Jumde, Vr
Petricci, E
Petrucci, C
Santillo, N
Taddei, M
Vaccaro, L2.
Issue Date: 2015
Project: None 
Journal: ORGANIC LETTERS
Abstract: 
Phenols can be efficiently reduced by sodium formate and Pd/C as the catalyst in water and in the presence of amines to give the corresponding cyclohexylamines. This reaction works at rt for 12 h or at 60 °C under microwave dielectric heating for 20 min. With the exception of aniline, primary, secondary amines, amino alcohols, and even amino acids can be used as nucleophiles. The reductive process is based on a sustainable hydrogen source and a catalyst that can be efficiently recovered and reused. The protocol was developed into a continuous-flow production of cyclohexylamines in gram scale achieving very efficient preliminary results (TON 32.7 and TOF 5.45 h-1).
Description: 
76150
URI: http://hdl.handle.net/20.500.12779/6534
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.5b01842
Appears in Collections:Publications

Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.