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|Title:||Synthesis of 1,2,3-substituted pyrroles from propargylamines via a one-pot tandem enyne cross metathesis-cyclization reaction||Authors:||Chachignon, Helene
|Keywords:||pyrrole derivatives;microwave chemistry, sonochemistry, mechanochemistry;cycloaddition reactions;metathesis reactions||Issue Date:||2015||Project:||None||Journal:||JOURNAL OF ORGANIC CHEMISTRY||Abstract:||
Enyne cross metathesis of propargylamines with ethyl vinyl ether enables the one-pot synthesis of substituted pyrroles. A series of substituted pyrroles, bearing alkyl, aryl, and heteroaryl substituents, has been synthesized in good yields under microwave irradiation. The reactions are rapid and procedurally simple and also represent a facile entry to the synthetically challenging 1,2,3-substituted pyrroles. The value of the methodology is further corroborated by the conversion of pyrroles into 3-methyl-pyrrolines and the derivatization of the 3-methyl-substituent arising from the metathesis reaction.
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