Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6500
Title: A highly stereo-controlled protocol to prepare pipecolic acids based on Heck and cyclohydrocarbonylation reactions
Authors: Arena, G. and Cini
and Petricci, Elena 
and Randino, E.
and Taddei, R.
Issue Date: 2015
Project: None 
Journal: ORGANIC CHEMISTRY FRONTIERS
Abstract: 
A novel synthetic protocol based on an indium-mediated glyoxylate allylation, Heck coupling and Rh-catalysed cyclohydrocarbonylation (CHC) was established to access enantiomerically pure polysubstituted pipecolic acids. The key steps are the Heck reaction, which is performed exclusively using a phenone-oxime derived palladacycle and the domino hydroformylation-cyclisation of a styryl derivative obtained from the Heck coupling. The reaction scheme, proceeding with good stereoselectivity, is also suitable for the preparation of substituted piperidine derivatives
Description: 
76148
URI: http://hdl.handle.net/20.500.12779/6500
ISSN: 2052-4110
DOI: 10.1039/c5qo00025d
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