Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6452
Title: Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand
Authors: Ghosh, Arun K.
Brindisi, Margherita 
Yen, Yu Chen
Xu, Xiaoming
Huang, Xiangping
Devasamudram, Thippeswamy
Bilcer, Geoffrey
Lei, Hui
Koelsch, Gerald
Mesecar, Andrew D.
Tang, Jordan
Keywords: Alzheimer's disease; BACE-1; Memapsin 2; Protease inhibitors; β-secretase; Amyloid Precursor Protein Secretases; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Kinetics; Ligands; Molecular Dynamics Simulation; Protease Inhibitors; Protein Binding; Pyrazoles; Structure-Activity Relationship; Thiazoles; Drug Design; Biochemistry; Molecular Medicine; Molecular Biology; 3003; Drug Discovery3003 Pharmaceutical Science; Clinical Biochemistry; Organic Chemistry
Issue Date: 2015
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Description: 
206007
URI: http://hdl.handle.net/20.500.12779/6452
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2014.11.087
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