Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6442
Title: The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease
Authors: DI PISA, Flavio
Pozzi, Cecilia 
Benvenuti, Manuela 
Andreini, Matteo
Marconi, Guido
Mangani, Stefano 
Keywords: Alzheimer disease; Crystal structure; Glutaminyl cyclase; Inhibitor screening; Inhibitors; Alzheimer Disease; Amino Acid Motifs; Aminoacyltransferases; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Gene Expression; Humans; Imidazoles; Models, Molecular; Molecular Sequence Data; Mutation; Nootropic Agents; Protein Engineering; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Fusion Proteins; Solubility; Structural Homology, Protein; Thiourea; Biophysics; Genetics; Structural Biology; Condensed Matter Physics; Biochemistry; Medicine (all)
Issue Date: 2015
Project: None 
Journal: ACTA CRYSTALLOGRAPHICA. SECTION F, STRUCTURAL BIOLOGY COMMUNICATIONS
Description: 
101993
URI: http://hdl.handle.net/20.500.12779/6442
ISSN: 2053-230X
DOI: 10.1107/S2053230X15010389
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