Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6418
Title: Protein-protein interactions and human cellular cofactors as new targets for HIV therapy
Authors: Tintori, Cristina
Brai, Annalaura
Fallacara, ANNA LUCIA
Fazi, Roberta
Schenone, Silvia
Botta, Maurizio 
Keywords: Adaptor Proteins, Signal Transducing; Anti-HIV Agents; Antigens, CD4; DEAD-box RNA Helicases; HIV Envelope Protein gp120; HIV Infections; HIV Integrase; Humans; Protein-Tyrosine Kinases; Receptors, CCR5; Transcription Factors; Drug Discovery3003 Pharmaceutical Science; Pharmacology; Medicine (all)
Issue Date: 2014
Project: None 
Journal: CURRENT OPINION IN PHARMACOLOGY
Abstract: 
Two novel approaches for the development of new drugs against AIDS are summarized each leading to the achievement of important discoveries in anti-HIV therapy. Despite the success of HAART in reducing mortality, resistant strains continue to emerge in the clinic, underscoring the importance of developing next-generation drugs. Protein protein interactions and human cellular cofactors represent the new targets of tomorrow in HIV research. The most relevant results obtained in the last few years by the two new strategies are described herein.
Description: 
74178
URI: http://hdl.handle.net/20.500.12779/6418
ISSN: 1471-4892
DOI: 10.1016/j.coph.2014.06.005
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