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|Title:||Protein-protein interactions and human cellular cofactors as new targets for HIV therapy||Authors:||Tintori, Cristina
Fallacara, ANNA LUCIA
|Keywords:||Adaptor Proteins, Signal Transducing; Anti-HIV Agents; Antigens, CD4; DEAD-box RNA Helicases; HIV Envelope Protein gp120; HIV Infections; HIV Integrase; Humans; Protein-Tyrosine Kinases; Receptors, CCR5; Transcription Factors; Drug Discovery3003 Pharmaceutical Science; Pharmacology; Medicine (all)||Issue Date:||2014||Project:||None||Journal:||CURRENT OPINION IN PHARMACOLOGY||Abstract:||
Two novel approaches for the development of new drugs against AIDS are summarized each leading to the achievement of important discoveries in anti-HIV therapy. Despite the success of HAART in reducing mortality, resistant strains continue to emerge in the clinic, underscoring the importance of developing next-generation drugs. Protein protein interactions and human cellular cofactors represent the new targets of tomorrow in HIV research. The most relevant results obtained in the last few years by the two new strategies are described herein.
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