Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6406
Title: Freeze-dried red wine effects on cardiac function and ECG of the Langendorff-perfused rat heart
Authors: Ferrara, Antonella
Fusi, Fabio 
Gorelli, Beatrice
Sgaragli, GIAN PIETRO
Saponara, Simona
Issue Date: 2014
Project: None 
Journal: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Abstract: 
The effect of freeze-dried red wine (FDRW) on cardiac function and electrocardiogram (ECG) in Langendorff-isolated rat hearts was investigated. FDRW significantly decreased left ventricular pressure and coronary perfusion pressure, the latter being dependent on the activation of both phosphatidylinositol 3-kinase and eNOS. FDRW did not affect the QRS and QT interval in the ECG, although at 56 μg of gallic acid equivalents/mL, it prolonged PQ interval and induced a second-degree atrioventricular block in 3 out of 6 hearts. This is the first study demonstrating that at concentrations resembling a moderate consumption of red wine, FDRW exhibited negative inotropic and coronary vasodilating activity leaving unaltered ECG, whereas at very high concentrations, it induced arrhythmogenic effects.
Description: 
59896
URI: http://hdl.handle.net/20.500.12779/6406
ISSN: 0008-4212
DOI: 10.1139/cjpp-2013-0262
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