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|Title:||Steroidal hydroxamic acid derivatives: A structurally novel class of hdac inhibitors||Authors:||Randino, R.
Some original chimeric structures formed by a hydroxamic acid moiety separated from a steroid nucleus (derived from cholanoic or abietic acids) by a seven atoms linker have been prepared and tested against the 11 HDAC isoforms. The products derived from abietic acid show promising results with a particular activity against Class IIb tubuline deaceyilating HDAC6
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