Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6396
Title: Proteomics of osteosarcoma.
Authors: Bernardini, Giulia 
Laschi, Marcella
Geminiani, Michela 
Santucci, Annalisa 
Issue Date: 2014
Project: None 
Journal: EXPERT REVIEW OF PROTEOMICS
Abstract: 
Osteosarcoma (OS) is the most common primary malignant tumor of bone and the third most common cancer in childhood and adolescence. Nowadays, early diagnosis, drug resistance and recurrence of the disease represent the major challenges in OS treatment. Post-genomics, and in particular proteomic technologies, offer an invaluable opportunity to address the level of biological complexity expressed by OS. Although the main goal of OS oncoproteomics is focused on diagnostic and prognostic biomarker discovery, in this review we describe and discuss global protein profiling approaches to other aspects of OS biology and pathophysiology, or to investigate the mechanism of action of chemotherapeutics. In addition, we present proteomic analyses carried out on OS cell lines as in vitro models for studying osteoblastic cell biology and the attractive opportunity offered by proteomics of OS cancer stem cells.
Description: 
60002
URI: http://hdl.handle.net/20.500.12779/6396
ISSN: 1478-9450
DOI: 10.1586/14789450.2014.900445
Appears in Collections:Publications

Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.