Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6375
Title: TRYPTOPHAN-BASED LINEAR DIPEPTIDESAND 1,4-DIKETOPIPERAZINES AS SIMPLIFIED SCAFFOLD OF THE NATURAL CYCLOTETRAPEPTIDE FR235222
Authors: Rodriquez, Manuela
Cini, Elena 
Petricci, Elena 
Anna Maria, D’Ursi
Carmela, Saturnino
Randino, Rosario
Issue Date: 2014
Project: None 
Journal: PHARMACOLOGYONLINE
Abstract: 
Design, synthesis and biological evaluation of simplified linear and cyclic peptidomimetic analogues of FR235222 (1), natural immunosuppressant and HDAC inhibitor, bearing hydroxyketone moiety as more stable zinc binding group, have been reported. Linear dipeptides (6a-b) show significant antiproliferative activities and are chosen to be promising lead compounds for further optimization, in order to elucidate molecule-enzyme surface recognition.
Description: 
93295
URI: http://hdl.handle.net/20.500.12779/6375
ISSN: 1827-8620
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