Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6366
Title: Synthesis of α,β-unsaturated aldehydes based on a one-pot phase-switch dehydrogenative cross-coupling of primary alcohols
Authors: Mura, Manuel G
De Luca, Lidia
Taddei, Maurizio 
Williams, Jonathan M. J
Porcheddu, Andrea
Keywords: Alcohols; Aldehydes; Catalysis; Molecular Structure; Ruthenium; Stereoisomerism
Issue Date: 2014
Project: None 
Journal: ORGANIC LETTERS
Abstract: 
An efficient one-pot ruthenium-catalyzed hydrogen-transfer strategy for a direct access to α,β-unsaturated aldehydes has been developed. The employment of enolates prepared in situ from alcohols avoided handling unstable aldehydes and provided a very appealing route to different cinnamaldehydes substituted in position 2. A silica-grafted amine was used as phase-switch tag leading to a selective one-pot process in favor of cross-dehydrogenative coupling products.
Description: 
65568
URI: http://hdl.handle.net/20.500.12779/6366
ISSN: 1523-7060
DOI: 10.1021/ol500916g
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