Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6359
Title: High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA-PB1 protein-protein interaction.
Authors: Tintori, Cristina
Laurenzana, Ilaria
Fallacara, Al
Kessler, U
Pilger, B
Stergiou, L
Botta, Maurizio 
Issue Date: 2014
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract: 
A high-throughput molecular docking approach was successfully applied for the selection of potential inhibitors of the Influenza RNA-polymerase which act by targeting the PA-PB1 protein-protein interaction. Commercially available compounds were purchased and biologically evaluated in vitro using an ELISA-based assay. As a result, some compounds possessing a 3-cyano-4,6-diphenyl-pyridine nucleus emerged as effective inhibitors with the best ones showing IC50 values in the micromolar range.
Description: 
61846
URI: http://hdl.handle.net/20.500.12779/6359
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2013.11.019
Appears in Collections:Publications

Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.