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|Title:||States of water, surface and rheological characterisation of a new biohydrogel as articular cartilage substitute||Authors:||Leone, Gemma
|Keywords:||POLY(VINYL ALCOHOL) HYDROGEL; HYDROXYAPATITE; SPECTROSCOPY; REPLACEMENT; DERIVATIVES; COMPOSITE||Issue Date:||2013||Project:||None||Journal:||POLYMERS FOR ADVANCED TECHNOLOGIES||Abstract:||
PVA based hydrogel was synthesised using, as crosslinking agent, trisodium trimetaphosphate (STMP) and its morphology was modified inducing a microporous structure to obtain potential substitutes for cartilage tissue. The hydrogel was characterised by Infrared Spectroscopy combined with Time of flight mass spectrometry (ToF-SIMS) that confirmed the successful occurrence of crosslinking reaction, the hyphotised crosslinking arm and its homogeneous distribution. The mechanical spectra of the fully hydrated samples confirmed covalently crosslinked systems with a rheological behaviour similar to that of tibial cartilage. Further analysis in terms of water content measurements, thermal stability and cytotoxicity confirmed the applicability of such a hydrogel as cartilage substitute.
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