Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6240
Title: Quercetin mitochondriotropic derivatives antagonize nitrate tolerance and endothelial dysfunction of isolated rat aorta rings
Authors: Durante, Miriam
Sgaragli, GIAN PIETRO
Biasutto, L.
Mattarei, A.
Fusi, Fabio 
Issue Date: 2013
Project: None 
Journal: PLANTA MEDICA
Abstract: 
Chronic use of glyceryl trinitrate is limited by serious side effects, inter alia tolerance and endothelial dysfunction of coronary and resistance arteries. The natural flavonoid quercetin has been shown to counteract the development of glyceryl trinitrate tolerance in vitro. Two mitochondriotropic, 4-O-triphenylphosphoniumbutyl derivatives of quercetin (QTA-3BTPI and Q-3BTPI) were compared to quercetin for protection against glyceryl trinitrate-induced tolerance and endothelial dysfunction of isolated rat aorta rings. Both QTA-3BTPI and Q-3BTPI significantly counteracted the reduced vascular responsiveness to both glyceryl trinitrate and acetylcholine caused by prolonged exposure of the vessel to glyceryl trinitrate itself, their potency being much greater than that of quercetin. QTA-3BTPI, however, turned out to cause endothelial dysfunction per se. Since Q-3BTPI antagonized in vitro nitrate tolerance and endothelial dysfunction of vessels, this encourages assessing whether this effect is displayed also in vivo during long-term glyceryl trinitrate treatment.
Description: 
59623
URI: http://hdl.handle.net/20.500.12779/6240
ISSN: 0032-0943
DOI: 10.1055/s-0032-1328293
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