Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6226
Title: Small molecules modulation of 14-3-3 protein–protein interactions
Authors: Mori, Mattia 
Vignaroli, Giulia
Botta, Maurizio 
Issue Date: 2013
Project: None 
Journal: DRUG DISCOVERY TODAY: TECHNOLOGIES
Abstract: 
14-3-3 is a family of highly conserved regulatory proteins which is attracting a significant interest due to its potential role as target for pharmacological intervention against cancer and neurodegenerative disorders. Although modulating protein-protein interactions (PPI) is still conceived as a challenging task in drug discovery, in past few years peptide inhibitors and small molecular modulators of 14-3-3 PPI have been described. Here we examine structural and biological features of 14-3-3 and propose an overview on techniques used for discovering small molecular inhibitors and stabilizers of 14-3-3 PPI.
Description: 
60091
URI: http://hdl.handle.net/20.500.12779/6226
ISSN: 1740-6749
DOI: 10.1016/j.ddtec.2012.10.001
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