Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6147
Title: New hyaluroran derivative with prolonged half-life for ophthalmogical formulation
Authors: Leone, Gemma 
Consumi, Marco 
Lamponi, Stefania 
Magnani, Agnese 
Keywords: Hyaluronan; Phosphorylation; Viscosity; Enzymatic degradation
Issue Date: 2012
Project: None 
Journal: CARBOHYDRATE POLYMERS
Abstract: 
Two new hyaluronan derivatives containing phosphate or cystamine groups have been synthesised to obtain tear drops with improved rheological properties and prolonged half-life. Rheological analysis, in terms of apparent viscosity, pointed out that phosphorylated hyaluronan showed promising characteristics for the foreseen application. The presence of phosphate groups along the chains, confirmed by infrared analysis, induced a strengthening in hyaluronan hydrogen bond capability thus modifying its thermal behaviour and prolonging its resistance against hyaluronidase attack. Finally, in vitro cytoxicity tests excluded any adverse effect of the developed hyaluronan derivative.
Description: 
40379
URI: http://hdl.handle.net/20.500.12779/6147
ISSN: 0144-8617
DOI: 10.1016/j.carbpol.2011.12.047
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