Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6111
Title: One dose of an MF59-adjuvanted pandemic A/H1N1 vaccine recruits pre-existing immune memory and induces the rapid rise of neutralizing antibodies
Authors: Faenzi, Elisa
Zedda, Luisanna
Bardelli, Monia
Spensieri, Fabiana
Borgogni, Erica
Volpini, Gianfranco
Buricchi, Francesca
LAGHI PASINI, Franco
Capecchi, PIER LEOPOLDO
Montanaro, Fabio
Belli, Riccardo
Lattanzi, MARIA EMANUELA
Piccirella, Simona
Montomoli, Emanuele
Sohail Ahmed, Syed
Rappuoli, Rino 
Del Giudice, Giuseppe
Finco, Oretta
Castellino, Flora
Galli, Grazia
Keywords: influenza; pandemic; vaccine
Issue Date: 2012
Project: None 
Journal: VACCINE
Abstract: 
Protective antibody responses to a single dose of 2009 pandemic vaccines have been observed in the majority of healthy subjects aged more than 3 years. These findings suggest that immune memory lymphocytes primed by previous exposure to seasonal influenza antigens are recruited in the response to A/H1N1 pandemic vaccines and allow rapid seroconversion. However, a clear dissection of the immune memory components favoring a fast response to pandemic vaccination is still lacking. Here we report the results from a clinical study where antibody, CD4+ T cell, plasmablast and memory B cell responses to one dose of an MF59-adjuvanted A/H1N1 pandemic vaccine were analyzed in healthy adults. While confirming the rapid appearance of antibodies neutralizing the A/H1N1 pandemic virus, we show here that the response is dominated by IgG-switched antibodies already in the first week after vaccination. In addition, we found that vaccination induces the rapid expansion of pre-existing CD4+ T cells and IgG-memory B lymphocytes cross-reactive to seasonal and pandemic A/H1N1 antigens. These data shed light on the different components of the immune response to the 2009 H1N1 pandemic influenza vaccination and may have implications in the design of vaccination strategies against future influenza pandemics.
Description: 
57229
URI: http://hdl.handle.net/20.500.12779/6111
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2012.04.020
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