Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6107
Title: Perinatal outcome and placental histological characteristics: a single-center study.
Authors: Perrone, Serafina
Toti, Paolo
Toti, MARIA STEFANIA
Badii, Silvia
Becucci, Elisa
Gatti, Mg
Marzocchi, Barbara 
Picardi, Anna
Buonocore, Giuseppe
Issue Date: 2012
Project: None 
Journal: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Abstract: 
OBJECTIVE: Placental pathology assists in characterizing the antenatal environment and may provide information about the baby's subsequent development. We aim to assess whether histological patterns of placenta are associated with an increased risk of perinatal diseases and to evaluate how different patterns of placental dysfunction can affect the neurodevelopmental outcome. METHODS: We analyzed the histopathological characteristics of 105 singleton placentas from infants born between 23 and 31 weeks of gestation and we assessed pair-wise correlations with perinatal diseases. Estimated relative risks were calculated from odds ratios. RESULTS: Histological chorioamnionitis (CA group) was detected on 51 of 100 placentas tested. Lesions of uteroplacental circulation (abruption, infarction or thrombosis, perivillous fibrin deposition, syncytial knots; vasculopathy group) were detected on 29. 25 normal placentas served as controls. The incidence of bronchopulmonary dysplasia (BPD) and patent ductus arteriosus (PDA) was higher in CA than in control group. The risk of developing retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH) and PDA was higher in CA than in vasculopathy group. CONCLUSIONS: At low gestational age CA, rather than placental lesions of vasculopathy, negatively impacts perinatal outcome. Clinical significance of histologic vasculopathy remains questionable. Other pathophysiological mechanisms than those associated with placental changes may occur following dysfunction of uteroplacental circulation.
Description: 
43317
URI: http://hdl.handle.net/20.500.12779/6107
ISSN: 1476-7058
DOI: 10.3109/14767058.2012.664344
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