Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6101
Title: HIV-1 proteins join the family of LIM kinase partners. New roads open up for HIV-1 treatment
Authors: Manetti, Fabrizio 
Issue Date: 2012
Project: None 
Journal: DRUG DISCOVERY TODAY
Abstract: 
LIM kinases (LIMK) exert their functions by recruiting many macromolecular partners that could contribute to modulate LIMK activity in a positive or negative manner. In addition to proteins that interact with LIMK in human or animal cells and tissues, recent data show that LIMK activity is also influenced by HIV-1 viral proteins. These results suggest new strategies for the treatment of HIV-1 infection, based on the inhibition of LIMK-mediated cofilin inactivation and consequent actin depolymerization. Further efforts are however required to unravel the mechanism by which the virus interferes with LIMK activity and with the right balance of actin remodeling.
Description: 
25335
URI: http://hdl.handle.net/20.500.12779/6101
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2011.08.004
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