Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6097
DC FieldValueLanguage
dc.contributor.authorLamponi, Stefaniaen_us
dc.contributor.authorLeone, Gemmaen_us
dc.contributor.authorM., Consumien_us
dc.contributor.authorG., Grecoen_us
dc.contributor.authorMagnani, Agneseen_us
dc.date.accessioned2021-03-30T15:59:39Z-
dc.date.available2021-03-30T15:59:39Z-
dc.date.issued2012-
dc.identifier.issn0920-5063en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/6097-
dc.description27182en_US
dc.description.abstractIn order to synthesize injectable hydrogels suitable as vitreous body substitutes, a new method based on the use of trisodium trimetaphosphate (STMP) to cross-link PVA was recently proposed. Hydrogels with differentmolar ratios between STMP and PVA were realised. The aim of the present study was the evaluation of the biocompatibility of the different STMP/PVA hydrogels synthesised by analysing the effects of their in vitro interaction with cultures of mouse fibroblasts NIH3T3, primary human microvascular endothelial cells adult (HMVECad) and human lens cells. Cytotoxicity of hydrogels was first evaluated by analysing cell density and proliferation. Morphological and morphometric analysis of cell in contact with hydrogels was then performed using light microscopy and scanning electron microscopy, respectively. Moreover, cell adhesion and growth onto the hydrogels surface was evaluated and correlated to the amount of adsorbed proteins. At last, the biocompatibility of the sheared STMP/PVA 1:8 hydrogel was tested. The in vitro data of all the STMP/PVA hydrogels demonstrated their good biocompatibility, and indicated that the 1:8 sample was the most promising as vitreous body substitute.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofJOURNAL OF BIOMATERIALS SCIENCE POLYMER EDITIONen_US
dc.subjectHydrogels; cytotoxicity; biocompatibility; vitreous body; fibroblasts; endothelial cells; human lens cellsen_US
dc.titleIN VITRO BIOCOMPATIBILITY OF NEW PVA-BASED HYDROGELS AS VITREOUS BODY SUBSTITUTESen_US
dc.typeArticleen_US
dc.identifier.doi10.1163/092050611X554499en_US
dc.identifier.scopus2-s2.0-82955207682en_US
dc.identifier.isiWOS:000297809800032en_US
dc.relation.volume23en_US
dc.description.firstpage555en_US
dc.description.lastpage575en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-2788-8797-
crisitem.author.orcid0000-0002-0820-6068-
crisitem.author.orcid0000-0002-6960-9418-
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