Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6076
Title: Prevalence of isolated atrial amyloidosis in young patients affected by congestive heart failure
Authors: Millucci, Lia 
Ghezzi, Lorenzo
Bernardini, Giulia 
Braconi, Daniela 
Tanganelli, Piero
Santucci, Annalisa 
Keywords: CONGO RED; FIBRILLATION; DISEASE; FLUORESCENCE
Issue Date: 2012
Project: None 
Journal: THE SCIENTIFIC WORLD JOURNAL
Abstract: 
Atrial natriuretic peptide (ANP), whose amyloid is responsible of isolated atrial amyloidosis (IAA), is known to play an important role in the pathophysiology of congestive heart failure (CHF). We provide here the microscopic examination of atrial biopsies from 36 young (mean 40 years) CHF patients distinguished in idiopathic dilated cardiomyopathy (DC) affected and hypertrophic Cardiomyopathy (HC) affected, endorsing the presumptive association of early CHF with IAA. We utilized a multiple method, using Congo red (CR) staining, CR fluorescence (CRF), and immunohistochemistry to assess the presence of IAA in CHF. Immunostaining showed a moderate deposition of IAA in the atrium surrounding working myocardium with small intracellular deposits. Our findings suggest a monitoring of young CHF cases for the development of IAA. Our study also demonstrated how the concurrent use of immunohistochemistry, CR, and CRF may greatly enhance the detection of low-grade amyloid deposits.
Description: 
39711
URI: http://hdl.handle.net/20.500.12779/6076
ISSN: 1537-744X
DOI: 10.1100/2012/293863
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