Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6005
Title: Developing Pyrrole-Derived Antimycobacterial Agents: a Rational Lead Optimization Approach
Authors: Biava, M
PORRETTA G., C
Poce, G
Battilocchio, C
Alfonso, S
DE LOGU, A
Manetti, Fabrizio 
Botta, Maurizio 
Issue Date: 2011
Project: None 
Journal: CHEMMEDCHEM
Abstract: 
Tuberculosis (TB) represents a never-ending challenge toward which research efforts are needed. Drug resistance is the key problem that scientists in the field need to fight. The development of new drugs endowed with novel modes of action against different biological targets is of extreme importance; these new agents should also exhibit lower toxicity compared with the anti-TB drugs currently available. Furthermore, new drugs should be inexpensive since most of the TB-infected population lives in developing nations. In the last few years, numerous researchers have focused their attention on TB, leading to the discovery of some interesting compounds. Among these, the pyrrole-derived compounds we developed can be considered very promising antimycobacterial agents. Aided by molecular modeling studies, we synthesized numerous compounds characterized by the same 1,5-diarylpyrrole scaffold and elucidated very interesting antitubercular/antimycobacterial properties. Some compounds identified are extremely promising and represent a step towards the design of novel lead structures in the fight against TB. Our efforts to this end are reviewed here.
Description: 
25200
URI: http://hdl.handle.net/20.500.12779/6005
ISSN: 1860-7179
DOI: 10.1002/cmdc.201000526
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