Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/6002
Title: A PVA/PVP hydrogel for human lens substitution: Synthesis, rheological characterization, and in vitro biocompatibility
Authors: Leone, Gemma 
Consumi, Marco 
Greco, Giuseppe
Bonechi, Claudia 
Lamponi, Stefania 
Rossi, Claudio 
Magnani, Agnese 
Keywords: human crystalline lens; rheology; hydrogel; poly(vinyl alcohol); poly(N-vinyl-2- pyrrolidinone)
Issue Date: 2011
Project: None 
Journal: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART B, APPLIED BIOMATERIALS
Abstract: 
To overcome opacification and absence of accommodation of human lens substitutes a new poly(vinyl alcohol) (PVA)/poly(N-vinyl-2- pyrrolidinone) (PVP) based hydrogel (PPS31075) was realised. The Infrared Spectroscopy and the mechanical spectra confirmed the successful occurrence of crosslinking reaction. The rheological analysis pointed out a behavior comparable with that of young human lens in terms of complex shear modulus and accommodation capability. Further analysis in terms of optical properties, water content measurements, diffusion coefficient, cytotoxicity, and human capsular cell adhesion confirmed the applicability of such a hydrogel as potential human lens substitute.
Description: 
42364
URI: http://hdl.handle.net/20.500.12779/6002
ISSN: 1552-4981
DOI: 10.1002/jbm.b.31813
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