Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5991
DC FieldValueLanguage
dc.contributor.authorCappelli, Andreaen_us
dc.contributor.authorManini, Monicaen_us
dc.contributor.authorPaolino, Marcoen_us
dc.contributor.authorA., Gallellien_us
dc.contributor.authorAnzini, Maurizioen_us
dc.contributor.authorL., Mennunien_us
dc.contributor.authorM., DEL CADIAen_us
dc.contributor.authorF., DE RIENZOen_us
dc.contributor.authorM. C., Menzianien_us
dc.contributor.authorVomero, Salvatoreen_us
dc.date.accessioned2021-03-30T15:56:40Z-
dc.date.available2021-03-30T15:56:40Z-
dc.date.issued2011-
dc.identifier.issn1948-5875en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5991-
dc.description36919en_US
dc.description.abstractThe serotonin 5-HT3 receptor is a ligand-gatedion channel, which by virtue of its pentameric architecture, canbe considered to be an intriguing example of intrinsicallymultivalent biological receptors. This paper describes a generaldesign approach to the study of multivalency in this multimericion channel. Bivalent ligands for 5-HT3 receptor have beendesigned by linking an arylpiperazine moiety to probes showingdifferent functional features. Both homobivalent and heterobivalentligands have shown 5-HT3 receptor affinity in thenanomolar range, providing evidence for the viability of ourdesign approach. Moreover, the high affinity shown by homobivalentligands suggests that bivalency is a promising approachin 5-HT3 receptor modulation and provides the rational basis for applying the concepts of multivalency to the study of 5-HT3receptor function.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofACS MEDICINAL CHEMISTRY LETTERSen_US
dc.titleBivalent Ligands for the Serotonin 5-HT3 Receptoren_US
dc.typeArticleen_US
dc.identifier.doi10.1021/ml2000388en_US
dc.identifier.pmid24900351-
dc.identifier.scopus2-s2.0-80051774769en_US
dc.identifier.isiWOS:000294075900003en_US
dc.relation.volume2en_US
dc.description.firstpage571en_US
dc.description.lastpage576en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0003-4140-3028-
crisitem.author.orcid0000-0003-1387-7875-
crisitem.author.orcid0000-0002-7481-5566-
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