Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5974
Title: Activation of the GABAB receptor prevents nicotine-induced locomotor stimulation in mice
Authors: Lobina, C.
Carai, M. A. M.
Froestl, W.
Mugnaini, Claudia 
Pasquini, Serena
Corelli, Federico 
G. e. s. s. a. G., L.
Colombo, G.
Issue Date: 2011
Project: None 
Journal: FRONTIERS IN PSYCHIATRY
Abstract: 
RecentstudiesdemonstratedthatactivationoftheGABABreceptor,eitherbymeansoforthostericagonistsorpositiveallostericmodulators(PAMs),inhibiteddifferentnicotine-relatedbehaviors,includingintravenousself-administrationandconditionedplaceprefer-ence,inrodents.Thepresentstudyinvestigatedwhethertheanti-nicotineeffectsoftheGABABreceptoragonist,baclofen,andGABABPAMs,CGP7930,andGS39783,extendtonicotinestimulanteffects.Tothisend,CD1micewereinitiallytreatedwithbaclofen(0,1.25,and2.5mg/kg,i.p.),CGP7930(0,25,and50mg/kg,i.g.),orGS39783(0,25,and50mg/kg,i.g.),thentreatedwithnicotine(0and0.05mg/kg,s.c.),andfinallyexposedtoanautomatedapparatusforrecordingoflocomotoractivity.Pretreatmentwithdosesofbaclofen,CGP7930,orGS39783thatdidnotalterlocomotoractivitywhengivenwithnico-tinevehiclefullypreventedhyperlocomotioninducedby0.05mg/kgnicotine.ThesedataextendtonicotinestimulanteffectsthecapacityofbaclofenandGABABPAMstoblockthereinforcing,motivational,andrewardingpropertiesofnicotine.ThesedatastrengthenthehypothesisthatactivationoftheGABABreceptormayrepresentapotentiallyuseful,anti-smokingtherapeuticstrategy.
Description: 
42284
URI: http://hdl.handle.net/20.500.12779/5974
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2011.00076
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