Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5965
DC FieldValueLanguage
dc.contributor.authorArioli, Fen_us
dc.contributor.authorBorrelli, Sen_us
dc.contributor.authorColombo, Fen_us
dc.contributor.authorFalchi, Fen_us
dc.contributor.authorFilippi, Ireneen_us
dc.contributor.authorCrespan, Een_us
dc.contributor.authorNaldini, Antonellaen_us
dc.contributor.authorScalia, Giusyen_us
dc.contributor.authorSilvani, Aen_us
dc.contributor.authorMaga, Gen_us
dc.contributor.authorCarraro, Fabioen_us
dc.contributor.authorBotta, Maurizioen_us
dc.contributor.authorPassarella, D.en_us
dc.date.accessioned2021-03-30T15:56:27Z-
dc.date.available2021-03-30T15:56:27Z-
dc.date.issued2011-
dc.identifier.issn1860-7187en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5965-
dc.description40376en_US
dc.description.abstractN-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine derivatives were synthesized and evaluated in vitro for their potential use as inhibitors of Bcr-Abl. The design is based on the bioisosterism between the 1,2,3-triazole ring and the amide group. The synthesis involves a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as the key step, with the exclusive production of anti-(1,4)-triazole derivatives. One of the compounds obtained shows general activity similar to that of imatinib; in particular, it was observed to be more effective in decreasing the fundamental function of cdc25A phosphatases in the K-562 cell line.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofCHEMMEDCHEMen_US
dc.titleN-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a scaffold for the synthesis of inhibitors of Bcr-Abl.en_US
dc.typeArticleen_US
dc.identifier.doi10.1002/cmdc.201100304en_US
dc.identifier.scopus2-s2.0-80055001778en_US
dc.identifier.isiWOS:000297416900012en_US
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21990039en_US
dc.relation.volume6en_US
dc.description.firstpage2009en_US
dc.description.lastpage2018en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0003-0456-6995-
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