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Title: Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone therapy
Authors: Bocci, Velio
Zanardi, Iacopo
Huijberts, M. S. P.
Travagli, Valter 
Keywords: Oxidative stress, Oxygen-ozonetherapy, Antioxidants, Heme-oxygenase-I, Advanced glycation end products
Issue Date: 2011
Project: None 
It is now well established that hyperglycemia, present in both type 1 and type 2 diabetes, causes a variety of biochemical derangements leading to a diffused vascular damage responsible for several pathologic manifestations. Although preclinical and clinical studies have been performed by an unreliable administration route, the correct approach of oxygen-ozonetherapy may break a vicious circle. Messengers, released by a precise interaction ex vivo of the patient’s blood with an equivalent calculated dose of ozone (0.42–0.84 mM), react with a variety of cells after blood infusion and restore a number of functions went astray. This paper aims to open a debate on this new therapy for improving the prognosis of diabetes.
ISSN: 1871-4021
DOI: 10.1016/j.dsx.2010.05.014
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