Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5960
Title: Chemical and Biological Properties of Polysaccharides-Coated Titania Nanoparticles: The Key Role of Proteins
Authors: Pasqui, Daniela
Golini, Lucia
DELLA GIOVAMPAOLA, Cinzia
Atrei, Andrea Massimo 
Barbucci, Rolando
Issue Date: 2011
Project: None 
Journal: BIOMACROMOLECULES
Abstract: 
In this study, we investigated the physicochemical and biological properties of naked and coated titania nanoparticles. The aim of this study was to verify the effect of the biopolymer coatings (hyaluronic acid and its biphosphonated derivative) and the role of protein adsorption from a cell culture medium on the citotoxicity of nanoparticles. Infrared spectroscopy (FT-IR) was used to investigate the interactions between the nanoparticles and the polysaccharides. The ζ potentials and the average hydrodynamic diameters of naked and coated nanoparticles dispersed in deionized water, medium with and without fetal bovine serum, were measured by means of dynamic light scattering (DLS). FT-IR and DLS measurements indicate that serum proteins are adsorbed on the NPs' surface. The biological tests show that naked and coated TiO(2) NPs do not induce an acute toxic effect on fibroblast cell cultures. This result shows that protein adsorption on NPs is an important factor in explaining the effect of NPs on cellular behavior.
Description: 
36480
URI: http://hdl.handle.net/20.500.12779/5960
ISSN: 1525-7797
DOI: 10.1021/bm101521e
Appears in Collections:Publications

Show full item record

Page view(s)

2
Last Week
2
Last month
2
checked on May 14, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.