Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5956
DC FieldValueLanguage
dc.contributor.authorL., Rossinien_us
dc.contributor.authorY., Hashimotoen_us
dc.contributor.authorH., Suzukien_us
dc.contributor.authorM., Kuritaen_us
dc.contributor.authorM., Gianfriddoen_us
dc.contributor.authorC., Scalien_us
dc.contributor.authorR., Roncaratien_us
dc.contributor.authorD., Franceschinien_us
dc.contributor.authorG., Pollioen_us
dc.contributor.authorTrabalzini, Lorenzaen_us
dc.contributor.authorG. C., Terstappen1en_us
dc.contributor.authorM., Matsuokaen_us
dc.contributor.authorA., Caricasoleen_us
dc.date.accessioned2021-03-30T15:56:23Z-
dc.date.available2021-03-30T15:56:23Z-
dc.date.issued2011-
dc.identifier.issn0892-6638en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5956-
dc.description20023en_US
dc.description.abstractHumanin (HN) is a 24-residue peptide displaying a protective activity in vitro against a range of cytotoxic and neurotoxic insults, as well as mediating in vivo amelioration of Alzheimer disease (AD)-related memory impairment in experimental models. Published evidence suggests that the mechanisms through which HN exerts its cyto- and neuroprotective activity may include its secretion and binding to membraneassociated receptors. Here, we describe the identification of a new modulator of HN neuroprotective activity, V-set and transmembrane domain containing 2 like (VSTM2L), previously known as C20orf102. VSTM2L interacts with HN in both yeast and mammalian cells, is secreted in cultured cells, is present in serum, and is selectively expressed in the central nervous system. VSTM2L colocalizes with HN in distinct brain areas as well as in primary cultured neurons, where it plays a role in the modulation of neuronal viability. When tested in HN neuroprotection bioassays, VSTM2L acts as a strong antagonist of HN neuroprotective activity. In summary, VSTM2L is the first example of a secreted antagonist of HN and may play a role in the modulation of HN biological functionsen_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofTHE FASEB JOURNALen_US
dc.titleVSTM2L is a novel secreted antagonist of the neuroprotective peptide Humaninen_US
dc.typeArticleen_US
dc.identifier.doi10.1096/fj.10-163535en_US
dc.identifier.pmid21393573en_US
dc.identifier.scopus2-s2.0-79957879593en_US
dc.identifier.isiWOS:000291023800021en_US
dc.relation.volume25en_US
dc.description.firstpage1983en_US
dc.description.lastpage2000en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0002-0850-7186-
Appears in Collections:Publications
Show simple item record

Page view(s)

6
Last Week
0
Last month
0
checked on Jun 13, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.