Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5954
DC FieldValueLanguage
dc.contributor.authorE., Balduccien_us
dc.contributor.authorA., Bonuccien_us
dc.contributor.authorM., Picchiantien_us
dc.contributor.authorPogni, Rebeccaen_us
dc.contributor.authorE., Tallurien_us
dc.date.accessioned2021-03-30T15:56:22Z-
dc.date.available2021-03-30T15:56:22Z-
dc.date.issued2011-
dc.identifier.issn1687-9767en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5954-
dc.description19328en_US
dc.description.abstractHNP-1 is an antimicrobial peptide that undergoes proteolytic cleavage to become a mature peptide. This process represents the mechanism commonly used by the cells to obtain a fully active antimicrobial peptide. In addition, it has been recently described that HNP-1 is recognized as substrate by the arginine-specific ADP-ribosyltransferase-1. Arginine-specific mono-ADPribosylation is an enzyme-catalyzed post-translational modification in which NAD+ serves as donor of the ADP-ribose moiety, which is transferred to the guanidino group of arginines in target proteins. While the arginine carries one positive charge, the ADP-ribose is negatively charged at the phosphate moieties at physiological pH. Therefore, the attachment of one or more ADPribose units results in amarked change of cationicity. ADP-ribosylation of HNP-1 drastically reduces its cytotoxic and antibacterial activities. While the chemotactic activity of HNP-1 remains unaltered, its ability to induce interleukin-8 production is enhanced. The arginine 14 of HNP-1 modified by the ADP-ribose is in some cases processed into ornithine, perhaps representing a different modality in the regulation of HNP-1 activities.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF PEPTIDESen_US
dc.titleStructural and Functional Consequences induced by post-translational modifications in α-Defensinsen_US
dc.typeArticleen_US
dc.identifier.doi10.1155/2011/594723en_US
dc.identifier.pmid21904558-
dc.identifier.scopus2-s2.0-84855311379en_US
dc.relation.volume2011en_US
dc.description.firstpage1en_US
dc.description.lastpage7en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0001-6681-1592-
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