Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5851
Title: Synthesis and Reactivity Studies on New Copper(II) Complexes: DNA Binding, Generation of Phenoxyl Radical, SOD and Nuclease Activities
Authors: Ghosh, K.
Kumar, P.
Tyagi, N.
Singh, U. P.
Aggarwal, V.
Baratto, Maria Camilla 
Keywords: Copper complexes; Electrochemistry; Galactose oxidase; Superoxide dismutase; DNA binding; Nuclease activity
Issue Date: 2010
Project: None 
Journal: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Abstract: 
Tridentate ligand PhimpH binds to Cu(II) centre after deprotonation affording a new family of complexes [Cu(Phimp)(H2O)]2(ClO4)2 (1), [Cu(Phimp)2] (2) and [Cu(Phimp)(L)] (3-5) where L are CH3COO-, SCN- and NO2- respectively. The molecular structures of complexes 1.CH3CN and 3 were determined by X-ray crystallography. Electrochemical studies depicted Cu(II)/Cu(I) couple in the range of 0.50 to 0.65 V vs. Ag/AgCl. EPR spectral studies for complexes 4 and 5 indicated the order of covalent character in 4 > 5 with dx2-y2 ground state. The phenoxyl radical complexes have been generated in situ by the oxidation of these complexes. Superoxide dismutase activity and DNA binding studies were examined. These complexes exhibited nuclease activity and the mechanism of DNA cleavage was investigated.
Description: 
23572
URI: http://hdl.handle.net/20.500.12779/5851
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2010.05.026
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