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|Title:||From Taxuspine X to structurally simplified Taxanes with remarkable P-Glycoprotein inhibitory activity||Authors:||Castagnolo, Daniele
S. I., Avramova
Sgaragli, GIAN PIETRO
|Keywords:||Taxanes; MDR reversing agents; P-glycoprotein; macrolactone||Issue Date:||2010||Project:||None||Journal:||ACS MEDICINAL CHEMISTRY LETTERS||Abstract:||
Three simplified “non-natural” natural taxanes, related to taxuspine X, were synthetized and assayed as P-glycoprotein (P-gp) inhibitors. One of them (6) proved to be a very efficient P-gp inhibitor with an IC50 = 7.2 × 10−6 M. In addition, to rationalize biological data, a pharmacophoric model was built through a ligand-based approach. This model represents the first example of a pharmacophore, which describes interactions of taxanes with P-gp.
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