Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5842
DC FieldValueLanguage
dc.contributor.authorMaccioni, Pen_us
dc.contributor.authorFlore, Pen_us
dc.contributor.authorCARAI M. A., Men_us
dc.contributor.authorMugnaini, Claudiaen_us
dc.contributor.authorPasquini, Serenaen_us
dc.contributor.authorCorelli, Federicoen_us
dc.contributor.authorGESSA G., Len_us
dc.contributor.authorColombo, G.en_us
dc.date.accessioned2021-03-30T15:55:33Z-
dc.date.available2021-03-30T15:55:33Z-
dc.date.issued2010-
dc.identifier.issn1664-0640en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12779/5842-
dc.description35634en_US
dc.description.abstractThe present study was designed to evaluate (a) alcohol self-administration behavior of selectively bred, Sardinian alcohol-preferring (sP) rats exposed to the so-called “sipper” procedure (characterized by the temporal separation between alcohol-seeking and -taking phases), and (b) the effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in sP rats exposed to this procedure. To this end, sP rats were initially trained to lever-respond under a reinforcement requirement (RR) 55 (RR55) for alcohol. Achievement of RR55 resulted in the 20-min presentation of the alcohol (15%, v/v)-containing sipper bottle. Once stable levels of lever-responding and alcohol consumption were reached, rats were treated with 0, 25, 50, and 100 mg/kg GS39783 (i.g.) 60 min before the self-administration session. Rats displayed robust alcohol-seeking (as suggested by relatively short latencies to the first lever-response and high frequencies of lever-responding) and -taking (as suggested by alcohol intakes averaging approximately 1.5 g/kg) behaviors. Pretreatment with GS39783 inhibited both alcohol-seeking (the number of rats achieving RR55 and the mean RR value were virtually halved) and -taking (the amount of self-administered alcohol was reduced by approximately 60%). The results of the present study suggest the power of the “sipper” procedure in triggering high levels of alcohol-seeking and -taking behavior in sP rats. Further, these results extend to this additional procedure of alcohol self-administration the capacity of GS39783 to reduce the motivational properties of alcohol and alcohol consumption in sP rats.en_US
dc.language.isoenen_US
dc.relationNoneen_US
dc.relation.ispartofFRONTIERS IN PSYCHIATRYen_US
dc.titleReduction by the positive allosteric modulator of the GABAB receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedureen_US
dc.typeArticleen_US
dc.identifier.pmid21423431en_US
dc.identifier.scopus2-s2.0-84861742811en_US
dc.relation.volume1en_US
dc.description.firstpage1en_US
dc.description.lastpage6en_US
dc.description.thirdmissionNot applicableen_US
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.orcid0000-0003-1998-732X-
crisitem.author.orcid0000-0002-5750-4504-
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