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|Title:||Anabaena sensory rhodopsin is a light-driven unidirectional rotor||Authors:||Strambi, A
|Issue Date:||2010||Project:||None||Journal:||PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA||Abstract:||
The implementation of multiconfigurational quantum chemistrymethods into a quantum-mechanics/molecular-mechanics protocolhas allowed the construction of a realistic computer model forthe sensory rhodopsin of the cyanobacterium Anabaena PCC7120. The model, which reproduces the absorption spectra of boththe all-trans and 13-cis forms of the protein and their associated Kand L intermediates, is employed to investigate the light-drivensteps of the photochromic cycle exhibited by the protein. It is foundthat the photoisomerizations of the all-trans and 13-cis retinalchromophores occur through unidirectional, counterclockwise 180°rotations of the!C14"C15!moiety with respect to the Lys210-linked end of the chromophore axis. Thus, the sequential interconversionsof the all-trans and 13-cis forms during a single photochromiccycle yield a complete (360°) unidirectional rotation of the!C14"C15!moiety. This finding implies that Anabaena sensoryrhodopsin is a biological realization of a light-driven molecularrotor.
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