Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5835
Title: Anabaena sensory rhodopsin is a light-driven unidirectional rotor
Authors: Strambi, A
Durbeij, B
Ferré, N
Olivucci, Massimo 
Issue Date: 2010
Project: None 
Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Abstract: 
The implementation of multiconfigurational quantum chemistrymethods into a quantum-mechanics/molecular-mechanics protocolhas allowed the construction of a realistic computer model forthe sensory rhodopsin of the cyanobacterium Anabaena PCC7120. The model, which reproduces the absorption spectra of boththe all-trans and 13-cis forms of the protein and their associated Kand L intermediates, is employed to investigate the light-drivensteps of the photochromic cycle exhibited by the protein. It is foundthat the photoisomerizations of the all-trans and 13-cis retinalchromophores occur through unidirectional, counterclockwise 180°rotations of the!C14"C15!moiety with respect to the Lys210-linked end of the chromophore axis. Thus, the sequential interconversionsof the all-trans and 13-cis forms during a single photochromiccycle yield a complete (360°) unidirectional rotation of the!C14"C15!moiety. This finding implies that Anabaena sensoryrhodopsin is a biological realization of a light-driven molecularrotor.
Description: 
20132
URI: http://hdl.handle.net/20.500.12779/5835
ISSN: 0027-8424
DOI: 10.1073/pnas.1015085107
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