Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5828
Title: Coordination pattern, solution structure and DNA damage studies of the copper(II) complex with the unusual aminoglycoside antibiotic hygromycin B
Authors: Gaggelli, Elena 
Gaggelli, Nicola 
Molteni, E
Valensin, Gianni 
Balenci, D
Wronska, M
Szczepanik, W
Nagaj, J
Skala, J
JEZOWSKA BOJCZUK, M.
Issue Date: 2010
Project: None 
Journal: DALTON TRANSACTIONS
Abstract: 
The aminoglycosidic antibiotic hygromycin B presents a peculiar chemical structure, characterized by two sugar rings joined via a spiro connection. The Cu(II) complex of hygromycin B in water solution was characterized by 1H-NMR, UV-Vis, EPR and CD spectroscopy, combined with potentiometric measurements. The spin–lattice relaxation enhancements were interpreted by the Solomon-Bloembergen-Morgan theory, allowing us to calculate copper-proton distances that were used to build a model of the complex by molecular mechanics and dynamics calculations. The fidelity of the proposed molecular model was checked by ROESY maps. Moreover DNA damage by the Cu(II)-hygromycin B system was also investigated, showing single and double strand scissions exerted by the complex at concentrations in the range 1–5 mM. Addition of either hydrogen peroxide or ascorbic acid to each sample resulted in the shift of the cleavage potency towards lower concentrations of the complex.
Description: 
35606
URI: http://hdl.handle.net/20.500.12779/5828
ISSN: 1477-9226
DOI: 10.1039/C0DT00458H
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