Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5825
Title: Cu(II) ion interaction with teicoplanin-vancomycin's analog
Authors: Brzezowska, M
KUCHARCZYK KLAMINSKA, M
Bernardi, F
Valensin, Daniela 
Gaggelli, Elena 
Gaggelli, Elena 
Valensin, Gianni 
JEZOWSKA BOJCZUK, M.
Keywords: Glycopeptide antibiotics; Teicoplanin; Copper coordination
Issue Date: 2010
Project: None 
Journal: JOURNAL OF INORGANIC BIOCHEMISTRY
Abstract: 
Teicoplanin, a member of the ‘‘last chance” antibiotic family has a similar structure and the same mechanism of action as parent drug vancomycin, which is proved to be an effective binder of Cu(II) ions. However, the potentiometric and spectroscopic studies (UV–visible, CD, NMR) have shown that the modification of the N-terminal structure of the peptide backbone in teicoplanin affects considerably the binding ability towards Cu(II) ions. While vancomycin forms almost instantly the stable 3 N complex species involving the N-terminal and two amide nitrogen donors, in case of teicoplanin only two nitrogen donors derived from the N-terminal amino group and adjacent peptide bond are coordinated to Cu(II) ion within the whole pH range studied. The major factor influencing the binding mode is most likely the structure of the N-terminus of the peptide unit in the antibiotic ligand.
Description: 
34972
URI: http://hdl.handle.net/20.500.12779/5825
ISSN: 0162-0134
DOI: 10.1016/j.jinorgbio.2009.11.001
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