Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5802
Title: Hit identification and biological evaluation of anticancer Pyrazolopyrimidines endowed with anti-inflammatory activity
Authors: S., Alcaro
A., Artese
Botta, Maurizio 
A. T., Zizzari
F., Orallo
F., Ortuso
S., Schenone
C., Brullo
M., Yànez
Issue Date: 2010
Project: None 
Journal: CHEMMEDCHEM
Abstract: 
Inhibiting COX: A small library of pyrazolopyriminines endowed with antiproliferative action was submitted to virtual screening against two COX isoforms. Three compounds were identified in silico as potentially selective COX-2 inhibitors. The biological assay confirmed one of them to be a COX-2 inhibitor with potency and selectivity comparable to known drugs.
Description: 
22444
URI: http://hdl.handle.net/20.500.12779/5802
ISSN: 1860-7179
DOI: 10.1002/cmdc.201000165
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