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|Title:||Hit identification and biological evaluation of anticancer Pyrazolopyrimidines endowed with anti-inflammatory activity||Authors:||S., Alcaro
A. T., Zizzari
Inhibiting COX: A small library of pyrazolopyriminines endowed with antiproliferative action was submitted to virtual screening against two COX isoforms. Three compounds were identified in silico as potentially selective COX-2 inhibitors. The biological assay confirmed one of them to be a COX-2 inhibitor with potency and selectivity comparable to known drugs.
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