Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12779/5774
Title: Identification of the First Non-Peptidic Small Molecule Inhibitor of the c-Abl/14-3-3 Protein-Protein Interactions Able to Drive Sensitive and Imatinib-Resistant Leukemia Cells to Apoptosis
Authors: Corradi, V
Mancini, M
Manetti, Fabrizio 
Petta, S
SANTUCCI M., A
Botta, Maurizio 
Keywords: 14-3-3 Proteins; Drug discovery; Leukemia; Molecular modeling; Non-peptidic compounds; Protein-protein interactions
Issue Date: 2010
Project: None 
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract: 
An in silico structure-based ligand design approach resulted in the identification of the first non-peptidic small molecule able to inhibit protein-protein interactions between 14-3-3 and c-Abl. This compound shows an anti-proliferative effect on human leukemia cells either sensitive or resistant to Imatinib, in consequence of the T315I mutation. It also mediates c-Abl release from 14-3-3 in a way similar to that found in response to Imatinib treatment.
Description: 
25197
URI: http://hdl.handle.net/20.500.12779/5774
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.08.019
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